A novel material based on an antibacterial choline-calixarene nanoassembly embedded in thin films

Abstract Supramolecular chemistry is one of the current strategies for producing advanced materials. With aim to develop new Thin-Films with antibacterial activity, we embedded an amphiphilic choline-calix[4]arene possessing properties in polymeric based on polyether-co-amide matrix (Pebax ® 2533). The loading calix[4]arene derivative film was performed by solution casting. amount calixarene additive films range 0.5–5 wt%. self-supported were characterized investigating phase miscibility, morphology, spectral properties, and gas transport. release from studied a biomimetic medium as PBS (10 mM, pH 7.4). presence did not affect thermal stability copolymer, whereas it induced increase crystallinity, wettability, permeability blend according its concentration. activity evaluated vitro against Escherichia coli Staphylococcus aureus strains, representative Gram-negative Gram-positive bacteria. developed displayed both strains. In particular, Pebax ? 5 wt% Chol-Calix caused within 10 h reduction E. S. 2.57 2 log CFU/mL, respectively. potential toxicity also tested mouse embryonic fibroblasts NIH/3T3. 2533/calixarene combination appears promising approach development novel flexible Graphical abstract